Year: 2019

Traditional NAFLD Activity Scoring Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent causes of liver dysfunction, with some estimates suggesting up to 30% of the general population as being affected (1). NAFLD, while mainly asymptomatic, can progress to non-alcoholic steatohepatitis (NASH) in a portion of individuals. NASH is characterized by multiple pathologic […]

When you finally arrive at a formulation that meets the target product profile, it is then necessary to devise a process by which it can be manufactured at scale. What started as a concept with beakers, stirring rods, and pipettes must become a process with bulk handling and automated or semi-automated equipment. Steps such as sifting, […]

So far, 2019 has been the year of building strong relationships between our members and reinforcing our ability to be a one-stop-shop CNS CRO thanks to our complimentary CNS platforms and our strong ensemble of experts. We participated in many of the main Neuroscience events worldwide and still have more to come (BIO Japan, Neuroscience […]

Sometimes you have no choice. “You can have any color you want ‘so long as it is black.’” “Ice cream sold here: vanilla.” You get the idea. So it is with formulation. A substance will demand certain treatment. An API with the solubility of brick dust requires a dosage form to enhance solubility. An API […]

The Role of Pharmaceutical Formulation Development Unlike other drug development activities, which are checkbox activities to meet FDA requirements, a good formulation solves a problem: “I’ve got this new molecule with fantastic in vitro activity, but how do I dose it? Will it be stable? Can I measure this? Is this suitable for the given […]

Sources of Impurities in Pharmaceutical Products In the development of a drug product, careful consideration needs to be given to impurities that may originate from manufacturing equipment, process components, and packaging materials. The majority of such impurities are common chemical additives used to improve the physicochemical properties of a wide range of plastic materials. Suppliers […]

Image Analysis: Enabling Data Powered Pathology The rise of whole slide imaging has enabled a variety of computational tools to facilitate the extraction of quantitative data from tissue samples on microscope slides. The practice of using computational algorithms to collect these data from whole slide images is known as “image analysis”. Image analysis has already […]

Monday, May 20, 2019, 12:00 PM – 5:00 PM, Copley Conf Rms A-D, San Diego, CA Overview Sharp investigators will present their exciting research in a showcase format as part of Sharp’s inaugural participation in 2019’s Clinical Trials Day celebration! The showcase will include displays from Sharp research sites, Sharp research vendors, partners, CROs, pharmaceutical […]